16 research outputs found

    Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

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    BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

    Program projects and learning inquiries: institutional mediation of innovation in research for development

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    This paper explores innovation processes and institutional change within research for development (R4D). It draws on learning by Australian participants associated with the implementation of a three-year Australian-funded food security R4D programme in Africa, and in particular a sub- component designed to support and elicit this learning. The authors critically examine this attempt at institutional innovation via the creation of a ‘learning project’ (LP) in a larger programme. For systemic innovation to be achieved, it is concluded that the system of concern must envisage institutional innovation and change within the donor and external research organizations as well as with project recipients and collaborative partners. Institutional constraints and opportunities are explored, including how the overall approach to learning in this programme could have been reframed as an organizational innovation platform (IP), designing, managing and evaluating IPs at different systemic levels of governance – including within the collaborative programme with African partners, in the constituent in-country projects, in the collaborating Australian organizations and at the level of personal practice

    Learning Participation as Systems Practice

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    Learning participation only makes sense if it is purposeful. From our perspective its primary purpose is to achieve more effective managing in situations of complexity and change. We describe our evolving understandings and practices (a praxeology) for Systems Practice for managing complexity, built on 30 years of developing supported open learning opportunities in the area of Systems within the curriculum of The Open University (UK). We ground this description in two specific examples of how notions of participation are incorporated conceptually and practically into a learner's programme of study by considering: i) the postgraduate course 'Environmental Decision Making. A Systems Approach' (T860) and ii) the undergraduate course 'Managing Complexity. A Systems Approach' (T306). From these courses, as well as a historical review of teaching practice, we identify nine pedagogic design features of our practice. Metaphorically all of the elements of our praxeology can be understood through the lens of the practitioner as chorographer (a systematic describer and analyst of regions) and choreographer (one versed in creating a dance of the emotions)
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